CP 154526
CAS No. : 157286-86-7
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| Cat. No. : | HY-12130 |
| M.Wt: | 364.53 |
| Formula: | C23H32N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities[1][2].
In Vitro:CP 154526 displaces [125I][Tyr0]CRF from rat hippocampal CRF receptors (IC50 = 0.5 nM) and from pituitary CRF receptors (IC50 = 0.04 nM)[2].
In Vivo:CP 154526 (1-10 mg/kg; i.p.; once) exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2].
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