Antalarmin
CAS No. : 157284-96-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $290 | In-stock |
| 10mg | $490 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-124475 |
| M.Wt: | 378.55 |
| Formula: | C24H34N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier[1][2][3].
IC50 & Target:Ki: 2.7 nM (CRHR1)[3]
In Vitro: Antalarmin inhibits the effect of corticotrophin-releasing factor (CRF) on Aβ1-42 levels through the cAMP/PKA signaling pathway[2].
In Vivo: Antalarmin (10 mg/kg; i.p.; daily for 4 weeks) leads to an improvement of chronic mild stress (CMS)-induced modifications in mice[1].
Antalarmin (20 mg/kg; i.p.; daily for 7 days) significantly reduces Aβ1-42 levels in sub-acute stressed Tg2576 mice[2].
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