L-159282


CAS No. : 157263-00-8

(Synonyms: MK 996)

157263-00-8
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Cat. No. : HY-19191
M.Wt: 524.63
Formula: C30H28N4O3S
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 157263-00-8 :

L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. In Vivo: In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1].

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