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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19191 |
| M.Wt: | 524.63 |
| Formula: | C30H28N4O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. In Vivo: In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1].
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