O-7460
CAS No. : 1572051-31-0
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| Cat. No. : | HY-120851 |
| M.Wt: | 478.62 |
| Formula: | C25H48FO5P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
O-7460 is a potent and selective DAGLα inhibitor, with an IC50 of 0.69 μM. O-7460 shows selectivity over onoacylglycerol lipase (MAGL), human CB1 and CB2 cannabinoid receptors. O-7460 can decrease HFD-caused an up-regulation of 2-AG levels[1].
IC50 & Target: IC50: 0.69 μM (DAGLα)[1]
In Vitro: O-7460 (10 μM; 20 min) decreases the Ionomycin (3 μM)-induced formation of 2-AG in N18TG2 cells[1].
In Vivo: O-7460 (6-12 mg/kg; a single i.p.) induces a time- and dose-dependent decrease in high-fat diet (HFD) intake and counteracts the body weight increase of mice[1].
O-7460 (12 mg/kg; i.p.) decreases the HFD-caused an up-regulation of 2-AG levels in the hypothalamus and liver of mice[1].
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