2-Ethyl-3-methylpyrazine

2-Ethyl-3-methylpyrazine is a GABA_A receptor potentiator, Antibacterial agent and Antifungal agent, with a K_p of 1.14 mM for GABA_A. 2-Ethyl-3-methylpyrazine forms via the Maillard reaction in sunflower seeds and also exists in the crust of wheat bread. 2-Ethyl-3-methylpyrazine regulates mood or states of consciousness via central GABA_A receptors. 2-Ethyl-3-methylpyrazine inhibits the growth of Ralstonia solanacearum and Magnaporthe oryzae. 2-Ethyl-3-methylpyrazine acts as an anxiolytic. 2-Ethyl-3-methylpyrazine is one of the sources of cocoa aroma, imparting nutty, corn-like, burnt, cereal, roasted and earthy flavors to foods. 2-Ethyl-3-methylpyrazine can be used in studies related to anxiety disorders and plant bacterial, fungal and oomycete infections^[1][2][3]. In Vitro:2-Ethyl-3-methylpyrazine (0.01% (v/v), 0.8 mM) potently potentiates GABA-induced responses of bovine GABAₐ receptors expressed in Xenopus oocytes, with a maximum potentiation magnitude of 555% and a dissociation constant (K_p) of 1.14 mM^[1].
2-Ethyl-3-methylpyrazine (335-672 µg/mL) inhibits the growth of Ralstonia solanacearum in a dose-dependent manner, with an inhibition rate of up to 95.9% at the concentration of 672 µg/mL^[2].
2-Ethyl-3-methylpyrazine (168 µg/mL) completely inhibits the mycelial growth of Magnaporthe oryzae^[2].
2-Ethyl-3-methylpyrazine inhibits the growth of the phytopathogenic fungus Gibberella moniliformis^[2].
2-Ethyl-3-methylpyrazine inhibits the growth of the phytopathogenic fungus Phaeomoniella chlamydospora^[2]. In Vivo:2-Ethyl-3-methylpyrazine (25-100 mg/kg; i.p.; single dose) prolongs pentobarbital-induced sleeping time in mice, with a 25 mg/kg intraperitoneal dose doubling sleep duration relative to control^[1].
2-Ethyl-3-methylpyrazine (100 mg/kg; i.p.; twice daily; 2 days) exhibits anti-anxiety activity in Mus musculus, as shown by significant increases in open arm entries and open arm stay time in an elevated plus maze test following 100 mg/kg intraperitoneal dosing twice daily for 2 days^[1].