D-Arginine

D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine. D-arginine can be used in myeloma and neurological disease research^{[1][2][3][4][5][6][7][8]}.^[1]. In Vitro:D-arginine (10 μM) significantly antagonizes responses to norepinephrine in subcutaneous arteries isolated from healthy humans^[2].
In Vivo:D-arginine (1 mg/kg, i.v., caudal veins, every two days) sensitize osteosarcoma to radiotherapy in a mouse model of subcutaneous osteosarcoma^[3].
The number of D-arginine residues in cell-penetrating peptides (i.v.) significantly affects their cellular uptake behavior and systemic toxicity in mice^[4].
D-Arginine (700 mg/kg, i.p.) displays central stimulant properties and increases spontaneous motor activity in mice^[5].
D-arginine (i.p.) shows a light toxicity order (LD50: 2800 mg/kg) in mice^[5].
D-arginine (1400 mg/kg, i.p.) protects against Pentylenetetrazole-induced convulsions in mice^[5].
D-arginine (1000 mg/kg, p.o., 16 weeks) significantly alters various enzymes and metabolites in the arginine metabolic pathways in male SD rats^[6].
D-arginine (1000 mg/kg, s.c., coadministered with L-arginine) blocks antinociception elicited by L-arginine (HY-N0455) in mice with Carrageenin-induced hyperalgesia^[7].
D-arginine (20 mg/kg, s.c.) does not significantly alter the percentage of antinociception in mice^[8].