HIV-1 integrase inhibitor 8
CAS No. : 1568-80-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $26 | In-stock |
| 250mg | $32 | In-stock |
| 1g | $39 | In-stock |
| 5g | $119 | In-stock |
| 25g | $459 | In-stock |
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| Cat. No. : | HY-107485 |
| M.Wt: | 308.41 |
| Formula: | C21H24O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. In Vitro: HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1].The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1].
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