Sulpiride
CAS No. : 15676-16-1
| Size | Price | Stock |
|---|---|---|
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| Cat. No. : | HY-B1019 |
| M.Wt: | 341.43 |
| Formula: | C15H23N3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer[1][2][3].
In Vitro:Dopamine, Alzheimer's, depression, Anxiety, Sprague-Dawley rats, NMRI mouse, Parkinson’s disease, psychosis, MCF-7/Adr, Breast cancer, Dexamethasone, Drug combination，MCF-7/Adr, Cancer stem-like cells (CSCs)
In Vivo:Sulpiride (50 mg/kg; Subcutaneous injection; Single dose) can increase the dopamine level in Sprague-Dawley rats[2].
Sulpiride (5-20 mg/kg; Intraperitoneal injection; Single dose) improves memory, but induces anxiety in Parkinson's disease (PD) mice at a dose of 20 mg/kg[3].
Sulpiride (25-100 mg/kg; Oral gavage; Once daily for 18 days) can enhance the anti-tumor activity of dexamethasone (DEX) (HY-14648) (1 and 8 mg/kg) in combination with dexamethasone in nu/nu nude mice bearing MCF-7/Adr xenografts.Without significant toxicity to organs[4].
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