SM-1295
CAS No. : 1562375-46-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $820 | In-stock |
| 10mg | $1320 | In-stock |
| 25mg | $2380 | In-stock |
| 50mg | $3560 | In-stock |
| 100mg | $5340 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124181 |
| M.Wt: | 598.53 |
| Formula: | C29H36BrN5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 310 mg/mL (ultrasonic) |
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].
IC50 & Target: Kd: 3077 nM (XIAP-BIR3), 3.2 nM (c-IAP1-BIR3), 9.5 nM (c-IAP2-BIR3)[2].
In Vitro: SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of <10 nM and displays a selectivity of >900-fold for cIAP1 over XIAP[1].
SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231[1].
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