GTS-21 (dihydrochloride)
CAS No. : 156223-05-1
(Synonyms: DMXB-A; DMBX-anabaseine)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $96 | In-stock |
| 50mg | $180 | In-stock |
| 100mg | $280 | In-stock |
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| Cat. No. : | HY-14564A |
| M.Wt: | 381.30 |
| Formula: | C19H22Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.5 mg/mL (ultrasonic;warming);H2O : 50 mg/mL (ultrasonic) |
GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti?inflammatory and cognition?enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist[1][2]. In Vitro: GTS-21 bound to human α4β2 nAChR (Ki=20 nM) 100-fold more potently than to humanα7-nAChR, and is 18- and 2-fold less potent than (-)-nicotine at human α4β2 and a7 nAChR, respectively[1]. In Vivo: GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury[3].
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