Gallocyanine (chloride)
CAS No. : 1562-85-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $40 | In-stock |
| 25mg | $85 | In-stock |
| 50mg | $130 | In-stock |
| 100mg | $210 | In-stock |
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| Cat. No. : | HY-D0961 |
| M.Wt: | 336.73 |
| Formula: | C15H13ClN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals[1][2][3][4].
In Vitro:Gallocyanine chloride (0-20 μM, 48 h) promotes the proliferation of breast cancer cells MDA-MB-231 and 4T1, inhibits the lipid peroxidation, improves the levels of GSH and SLC7A11[2].
In Vivo:Gallocyanine chloride (10 mg/kg, iv, every 2 days for 3 weeks) inhibits the breast cancer lung metastasis in mouse MDA-MB-231 xenograft models[2].
Gallocyanine chloride (1 mg/kg, intratracheal instillation, once weekly for 4 weeks) reduces PM2.5-induced lung injury and fibrosis in mouse models[3].
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