Ivabradine
CAS No. : 155974-00-8
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| Cat. No. : | HY-B0162 |
| M.Wt: | 468.59 |
| Formula: | C27H36N2O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity[1][2][3][4].
In Vivo:Ivabradine (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice[3].
Ivabradine (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities[4].
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