PFM01
CAS No. : 1558598-41-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $175 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $450 | In-stock |
| 250mg | $800 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-116770 |
| M.Wt: | 293.40 |
| Formula: | C14H15NO2S2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 25 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR)[1][2].
IC50 & Target: Endonuclease[1]
In Vitro: PFM01 (100 μM) rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells[1].
PFM01 (100 μM) diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1].
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1].
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1].
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