GNE-9822
CAS No. : 1557232-32-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $540 | In-stock |
| 10mg | $880 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-12410 |
| M.Wt: | 420.55 |
| Formula: | C24H32N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
GNE-9822 is a potent, orally active and selective ITK inhibitor with a Ki value of 0.7 nM, and an EC50 value of 354.5 nM. GNE-9822 has good ADME properties. GNE-9822 can be used in research of asthma[1][2]. IC50 & Target:EC50: 354.5 nM (ITK)[2] In Vitro:GNE-9822 (compound 28) inhibits the phosphorylation of PLCγ with an IC50 value of 55 nM[1]. In Vivo:GNE-9822 (compound 28; po and iv; 1 and 5 mg/kg) has good bioavailability and halflives observed in mouse and rats[1].
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