Inogatran
CAS No. : 155415-08-0
(Synonyms: H-314-27)
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| Cat. No. : | HY-19660 |
| M.Wt: | 438.56 |
| Formula: | C21H38N6O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Inogatran (H-314-27) is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.
In Vivo: Inogatran (H-314-27; 0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis[1].
Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model[2].
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