BMT-090605
CAS No. : 1551403-51-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $560 | In-stock |
| 10mg | $890 | In-stock |
| 25mg | $1780 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-101290 |
| M.Wt: | 364.44 |
| Formula: | C21H24N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain[1].
IC50 & Target:IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1]
In Vitro:BMT-090605 shows AAK1inhibitory activity with an IC50 of 0.63 nM[1].
BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1].
In Vivo:BMT-090605 (intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1].
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