GSK199
CAS No. : 1549811-53-1
Price and Availability of
CAS No. : 1549811-53-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $240 | In-stock |
| 10mg | $365 | In-stock |
| 25mg | $657 | In-stock |
| 50mg | $921 | In-stock |
| 100mg | $1290 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-103058 |
| M.Wt: | 468.98 |
| Formula: | C24H29ClN6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Introduction of
1549811-53-1
:
GSK199 is an orally active, reversible, and selective PAD4 inhibitor with an IC50 of 200 nM in the absence of calcium. GSK199 can be used for the research of rheumatoid arthritis[1].
In Vitro:GSK199 (0-20 μM, 72 h) inhibits viral genome production in a dose-dependent manner (IC50 = 0.6 μM) in OC43-infected MRC-5 cells[2].
In Vivo:
Pharmacokinetic Analysis in Male Balb/C Mice[3]
| Route | Dose (mg/kg) | AUC0-∞ (ng·h/mL) | t1/2 (h) | Cmax (ng/mL) | F (%) |
| p.o. | 10 | 4192 | 1.48 | 1.73 | 63.6 |
| i.v. | 2 | 1342 | 1.58 | / | / |