Hematin
CAS No. : 15489-90-4
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| Cat. No. : | HY-W040030 |
| M.Wt: | 633.49 |
| Formula: | C34H33FeN4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 1.43 mg/mL (ultrasonic;warming;heat to 70°C) |
Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5].
In Vitro: Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin[2].
Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml[2].
Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)[2].
Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin[2].
In Vivo: Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g)[4].
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