Pomalidomide-5-OH
CAS No. : 1547162-41-3
(Synonyms: 5-Hydroxy pomalidomide; CC-17368)
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $400 | In-stock |
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| Cat. No. : | HY-123324 |
| M.Wt: | 289.24 |
| Formula: | C13H11N3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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