SB 204990
CAS No. : 154566-12-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $715 | In-stock |
| 100mg | $1144 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16450 |
| M.Wt: | 389.27 |
| Formula: | C18H22Cl2O5 |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. IC50 & Target:ACLY[1]. In Vitro: SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels[1]. In Vivo: SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels[2].
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