SP-100030
CAS No. : 154563-54-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $182 | In-stock |
| 25mg | $328 | In-stock |
| 50mg | $558 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110177 |
| M.Wt: | 437.65 |
| Formula: | C14H5ClF9N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC50s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA)[1][2].
In Vitro: SP-100030 blocks the production of IL-2 and IL-8 in Jurkat T-cells at the same concentrations as seen in the luciferase assay (IC50≈30 nM)[1].
ELISA and RT-PCR confirmed that IL-2, IL-8, and TNF-alpha production by activated Jurkat and other T cell lines were inhibited by SP100030[2].
In Vivo: SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].
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