CHM-1
CAS No. : 154554-41-3
(Synonyms: NSC656158)
| Size | Price | Stock |
|---|---|---|
| 1mg | $25 | In-stock |
| 5mg | $65 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $158 | In-stock |
| 50mg | $220 | In-stock |
| 100mg | $305 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103257 |
| M.Wt: | 283.25 |
| Formula: | C16H10FNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity[1][2][3].
IC50 & Target: IC50: 0.75 μM (HA22T)[1]
In Vitro: CHM-1 (0-100μM; 24 hours) induces significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells (IC50 = 0.75 μM)[1].
CHM-1 (0-10 μM; 24 hours) significantly increases the binding of cyclin B1 to Cdc2 in HA22T cells[1].
In Vivo: CHM-1 (10 mg/kg; I.p.) induces a dose-dependent inhibition of HA22T tumor growth[1].
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