Neamine (tetrahydrochloride)
CAS No. : 15446-43-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $150 | In-stock |
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| Cat. No. : | HY-115349 |
| M.Wt: | 468.20 |
| Formula: | C12H30Cl4N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].
In Vitro: Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1].
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1].
In Vivo: Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1].
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