Napsagatran
CAS No. : 154397-77-0
(Synonyms: Ro 46-6240; Ro 46-6240/010)
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| Cat. No. : | HY-15759 |
| M.Wt: | 558.65 |
| Formula: | C26H34N6O6S |
| Purity: | >98 % |
| Solubility: |
Napsagatran (Ro 46-6240) is a potent thrombin inhibitor. Napsagatran exhibits anticoagulant effects in vitro and in vivo. Napsagatran can be used in antithrombotic research[1][2].
In Vitro:Napsagatran (10 μg/kg/min) reduces platelet-rich thrombus formation in an ex vivo perfusion chamber model[1].
In Vivo:Napsagatran (3-10 μg/kg/min) significantly prevents coronary artery occlusion and reduces intracoronary thrombus formation in a canine model of electrically induced arterial thrombosis[1].
Napsagatran (10 μg/kg/min, i.v., infusion for 240 minutes) significantly reduces thrombus associated fibrin in rabbits[2].
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