Levonadifloxacin


CAS No. : 154357-42-3

(Synonyms: (S)-(-)-Nadifloxacin; WCK 771)

154357-42-3
Price and Availability of CAS No. : 154357-42-3
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25mg $240 In-stock
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100mg $800 In-stock
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Cat. No. : HY-14926
M.Wt: 360.38
Formula: C19H21FN2O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 125 mg/mL (ultrasonic)
Introduction of 154357-42-3 :

Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes[1]. In Vitro:Levonadifloxacin (32 μg/mL; 24 h) achieves a 90-99%?intracellular reduction of MSSA and MRSA strains phagocytized in THP-1 monocytes with MICs of 0.03 μg/mL and 15.0 ng/mL[1].
In Vivo:Levonadifloxacin (12.5-400 mg/kg; s.c.; single dose) shows efficacy in vivo against Staphylococcus aureus in a Neutropenic Murine Lung Infection Model[2].

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