Serpin B9-IN-1
CAS No. : 154235-77-5
(Synonyms: BTCA)
| Size | Price | Stock |
|---|---|---|
| 1g | $17 | In-stock |
| 5g | $46 | In-stock |
| 10g | $89 | In-stock |
| 25g | $217 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-33299 |
| M.Wt: | 163.13 |
| Formula: | C8H5NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1].
IC50 & Target:IC50: Serpin B9
In Vivo:Serpin B9-IN-1 (BTCA) inhibits bone metastasis (BM) in multiple tumor metastasis models. Serpin B9-IN-1 (50 mg/kg/d; ip; 14 d) effectively reduced the survival rate and metastasis proportion of metastatic cancer cells in the mouse bone metastasis model with LLC1-BM3 injected into the tail artery (CA)[1].
Serpin B9-IN-1 (300 μg/d; ip; 14 d) effectively delayed the average time to bone metastasis (BM) in the LLC1-BM3 cell group[1].
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