clasto-Lactacystin β-lactone


CAS No. : 154226-60-5

(Synonyms: Omuralide; β-Clastolactacystin)

154226-60-5
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Cat. No. : HY-108549
M.Wt: 213.23
Formula: C10H15NO4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 154226-60-5 :

Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor. IC50 & Target:20S proteasome[1] In Vitro: Clasto-Lactacystin β-lactone is a natural active metabolite of lactacystin, which is a metabolite of Streptomyces. Clasto-Lactacystin β-lactone is the cell cycle progression in an osteosarcoma cell line[1]. Clasto-Lactacystin β-lactone is an irreversible 20S proteasome inhibitor, and also acts as a partial inhibitor of branched amino acid preferring peptidase (BrAAP). β-Lactone inactivates approximately 60% of the BrAAP activity rapidly, and the remaining 40% of the BrAAP activity is inactivated by β-lactone at a 50-fold slower rate[2].

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