Vilagletistat
CAS No. : 1542132-88-6
(Synonyms: ZED-1227)
| Size | Price | Stock |
|---|---|---|
| 1mg | $350 | In-stock |
| 5mg | $647 | In-stock |
| 10mg | $987 | In-stock |
| 25mg | $1950 | In-stock |
| 50mg | $3120 | In-stock |
| 100mg | $4990 | In-stock |
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| Cat. No. : | HY-19359 |
| M.Wt: | 528.60 |
| Formula: | C26H36N6O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD)[1][2].
IC50 & Target:IC50: 45 nM (TG2)[2]
In Vitro: ZED-1227 (0.1 μΜ-1 μΜ; 24 hours) has no effect on metabolic activity and proliferation in Huh7 cells and CaCo2 cells, that suggests ZED-1227 has no cytotoxic activity[2].
ZED-1227 (0.002-0.2 mg/mL; 30 minutes) inhibits TG2 in the small intestinal mucosa in vitro[2].
In Vivo: ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice[1].
ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa[2].
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