p53-MDM2-IN-2
CAS No. : 1542066-69-2
Price and Availability of
CAS No. : 1542066-69-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $161 | Get quote |
| 5mg | $697 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-116052 |
| M.Wt: | 552.46 |
| Formula: | C30H26BrN5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Introduction of
1542066-69-2
:
p53-MDM2-IN-2 (Compound 5q) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-2 exerts antitumor activity by inhibiting NF-κB pathway[1].
In Vitro:p53-MDM2-IN-2 (0.1-20 μM, 4 h) dose-dependent increases p65 levels in A549 cytoplasm and nucleus[1].
In Vivo:p53-MDM2-IN-2 (200 mg/kg, gavage for 14 days) effectively inhibits tumor growth in A549 xenotransplantation model[1].
Pharmacokinetic Analysis in Sprague−Dawley Rats[1]
| Route | Dose (mg/kg) | Cmax (ng/mL) | AUClast (μg·h/L) | AUCINF_obs (g·h/L) | MRTINF_obs (h) | t1/2 (h) | Tmax (h) | Clobs (L·h/kg) | Vss_obs (L/kg) | F (%) |
| i.v. | 5 | 2548 | 1581 | 1589 | 1.21 | 2.11 | / | 3.18 | 9.74 | / |
| i.g. | 100 | 4589 | 23155 | 23161 | 4.99 | 1.80 | 3.25 | / | / | 72.9 |