Thiamine pyrophosphate
CAS No. : 154-87-0
(Synonyms: Cocarboxylase)
| Size | Price | Stock |
|---|---|---|
| 100mg | $50 | In-stock |
| 500mg | $160 | In-stock |
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| Cat. No. : | HY-113076 |
| M.Wt: | 460.77 |
| Formula: | C12H19ClN4O7P2S |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic);H2O : 41.67 mg/mL (ultrasonic) |
Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases[1][2][3].
In Vivo: Thiamine pyrophosphate (25 mg/kg, i.p.) inhibits the ischemia-reperfusion induced oxidative damage in rat ovarian tissue[1].
Thiamine pyrophosphate (20 mg/kg, i.p., once a day for 14 days) prevents Cisplatin (HY-17394) induced cardiotoxicity, and associated oxidative stress and heart injury in rats[2].
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