SML-8-73-1
CAS No. : 1536470-92-4
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| Cat. No. : | HY-19315 |
| M.Wt: | 562.75 |
| Formula: | C14H21ClN6O12P2 |
| Purity: | >98 % |
| Solubility: |
SML-8-73-1 is a nucleotide-based KRASG12C inhibitor. SML-8-73-1 can be used for the study of non-small cell lung cancer (NSCLC)[1][2].
In Vitro:SML-8-73-1 (2.5 μM, 2 h) can specifically and covalently modify KRASG12C, but not KRASWT[1].
SML-8-73-1 (2.5 μM, 2 h) can effectively bind to KRASG12C at high intracellular nucleotide concentrations, overcoming competitive inhibition[1].
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