Plevitrexed
CAS No. : 153537-73-6
(Synonyms: ZD 9331; BGC9331)
| Size | Price | Stock |
|---|---|---|
| 1mg | $980 | In-stock |
| 5mg | $2450 | In-stock |
| 10mg | $3920 | In-stock |
| 25mg | $7250 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-13728 |
| M.Wt: | 532.53 |
| Formula: | C26H25FN8O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical[1][2][3]. Plevitrexed is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro: ZD9331 inhibits the transport of [3H]-methotrexate into L1210 and W1L2 cells with a Ki of～1 μM[3].
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