Cevimeline (hydrochloride hemihydrate)
CAS No. : 153504-70-2
(Synonyms: SNI-2011; AF102B (hydrochloride hemihydrate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $594 | In-stock |
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| Cat. No. : | HY-76772 |
| M.Wt: | 244.78 |
| Formula: | C10H17NOS.HCl.1/2H2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB)[5]. IC50 & Target:Muscarinic M1 and M3 receptor[1] In Vitro: In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1]. In Vivo: Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].
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