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Desmethoxyyangonin


CAS No. : 15345-89-8

(Synonyms: Demethoxyyangonin; 5,6-Dehydrokavain)

15345-89-8
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Cat. No. : HY-N0918
M.Wt: 228.24
Formula: C14H12O3
Purity: >98 %
Solubility: DMSO : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 15345-89-8 :

Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant. Desmethoxyyangonin is a selective inhibitor of monoamine oxidase-B (MAO-B) (IC50: 0.123  µM). Desmethoxyyangonin exerts anti-inflammatory effects by inhibiting Jak2/STAT3 and IKK signaling pathways. Desmethoxyyangonin induces CYP3A23 expression and leads to skeletal muscle relaxation[1][2][3][4]. In Vitro:Desmethoxyyangonin (10-200 µM, 7-19 h) inhibits the activity of pro-inflammatory mediators in LPS-induced macrophages RAW 264.7[2].
Desmethoxyyangonin (50 µM, 3-9 h) inhibits Jak2/STAT3 and IKK signaling pathways in LPS-induced macrophages RAW 264.7[2].
Desmethoxyyangonin (25-100 µM, 48 h) inhibits CD4 cell activation and proliferation in a dose-dependent manner[2].
Desmethoxyyangonin (2-100 µM, 24-72 h) induces the expression of CYP3A23[4].
In Vivo:Desmethoxyyangonin (1 and 10 mg/kg, i.p., 3 days) reduces liver damage in the mouse LPS/D-GalN-induced fulminant hepatitis model[2].
Desmethoxyyangonin (20 mg/kg, i.p.) induces skeletal muscle relaxation in male Wistar rats[3].

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