COH000
CAS No. : 1534358-79-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $230 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $720 | In-stock |
| 25mg | $1300 | In-stock |
| 50mg | $1820 | In-stock |
| 100mg | $2545 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114304 |
| M.Wt: | 419.47 |
| Formula: | C25H25NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 35.71 mg/mL (ultrasonic) |
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1]. IC50 & Target: IC50: 0.2 μM (SUMO-activating enzyme)[1]. In Vitro: COH000 has over 500-fold selectivity for SUMOylation than ubiquitylation. COH000 inhibits SUMO adenylation without directly competing with ATP or SUMO1 binding. COH000 has an extremely slow off-rate and is consistent with it being covalently bound to the enzyme[1].
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