Lanicemine
CAS No. : 153322-05-5
(Synonyms: AZD6765)
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| Cat. No. : | HY-108235 |
| M.Wt: | 198.26 |
| Formula: | C13H14N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1?μM for NMDA receptor; IC50s of 4-7?μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1]. IC50 & Target: NMDA receptor[1] In Vivo: Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30?mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].
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