ML355
CAS No. : 1532593-30-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $900 | In-stock |
| 250mg | $1400 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-12341 |
| M.Wt: | 441.52 |
| Formula: | C21H19N3O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 42 mg/mL |
ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. IC50 & Target: IC50: 0.34 μM (12-LOX)[1] In Vitro: ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells[1]. In Vivo: ML355 (1.88-30 mg/kg; i.g.; 2 times per day for two days) strongly inhibits the thrombus formation in mice at higher dose compared to WT controls[3].
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