TRPV4/TRPA1-IN-1
CAS No. : 1532515-60-8
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| Cat. No. : | HY-122692 |
| M.Wt: | 399.56 |
| Formula: | C25H25N3S |
| Purity: | >98 % |
| Solubility: |
TRPV4/TRPA1-IN-1 is a TRPV4/TRPA1 inhibitor that suppresses TRPV4/TRPA1-mediated calcium influx. TRPV4/TRPA1-IN-1 alleviates pain behaviors in a mouse trigeminal stimulation pain model and inhibits inflammation and pain-related behaviors in a mouse acute pancreatitis model. TRPV4/TRPA1-IN-1 can be used in research on acute pancreatitis[1].
In Vitro:TRPV4-IN-4 (0-10 μM) inhibits TRPV4-mediated Ca2+ influx in N2a cells overexpressing TRPV4, primary porcine articular chondrocytes, and primary rat astrocytes (IC50 = 0.45 μM in N2a cells)[1].
TRPV4-IN-4 (5 μM; 5 min) effectively inhibits TRPV4-mediated transmembrane currents in TRPV4-GFP+ N2a cells[1].
TRPV4-IN-4 inhibits TRPA1 activity in N2a cells overexpressing TRPA1 (IC50 = 0.43 μM)[1].
In Vivo:TRPV4-IN-4 (10 mg/kg; i.p.; single dose) alleviates trigeminal inflammatory pain mediated by TRPV4 and TRPA1 in a mouse model of pain[1].
TRPV4-IN-4 (10 mg/kg, intraperitoneal injection, single dose) alleviates inflammation and pain associated with Caerulein (HY-A0190)-induced acute pancreatitis in mouse models, including the reduction of pancreatic edema and pain-related behaviors[1].
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