Fonsartan
CAS No. : 153235-15-5
(Synonyms: HR 720)
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| Cat. No. : | HY-19224 |
| M.Wt: | 620.87 |
| Formula: | C26H30K2N4O5S2 |
| Purity: | >98 % |
| Solubility: |
Fonsartan (HR720) is an AT1 receptor antagonist. Fonsartan can be used for the study of myocardial infarction (MI)[1][2]. In Vitro:Fonsartan selectively inhibits AT1 receptors (mainly in the adrenal cortex (IC50 = 1.5 × 10-8 M)) while having a lower affinity for AT2 receptors (mainly in the adrenal medulla (IC50 = 1.4 × 10-6 M))[2]. In Vivo:Fonsartan (3 mg/kg, s.c., once daily for 6 weeks) produces the most comprehensive cardioprotective effect when administered to rats with myocardial infarction (MI) modeling starting 3 to 24 hours after modeling[1].
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