U-74389G
CAS No. : 153190-29-5
(Synonyms: PNU74389G (meleate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $28 | In-stock |
| 10mg | $45 | In-stock |
| 25mg | $90 | In-stock |
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| Cat. No. : | HY-106592A |
| M.Wt: | 726.90 |
| Formula: | C41H54N6O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].
In Vitro:U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages[3].
In Vivo:U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change[2].
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3].
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