4-Chlorokynurenine
CAS No. : 153152-32-0
(Synonyms: 4-Cl-KYN; AV-101)
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| Cat. No. : | HY-108920 |
| M.Wt: | 242.66 |
| Formula: | C10H11ClN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure[1][2][3].
In Vivo:4-Chlorokynurenine (25-125 mg/kg, i.p.) inhibits depression in depressed CD-1 mice[1].
4-Chlorokynurenine (50 mg/kg, i.p., 10, 30, 120 and 360 mins after quinolinate injection) prevents hippocampal neurotoxicity in quinolinate-induced neurotoxic rats models[2].
4-Chlorokynurenine (L-4-Chlorokynurenine) (50 mg/kg, i.p., 10, 30, 120 and 360 mins after kainate) attenuates kainate-induced seizures and neuronal loss in the rats[3].
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