Diclofenac (Sodium) (Standard)
CAS No. : 15307-79-6
(Synonyms: GP 45840 (Standard))
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| Cat. No. : | HY-15037R |
| M.Wt: | 318.13 |
| Formula: | C14H10Cl2NNaO2 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
Diclofenac (Sodium) (Standard) is the analytical standard of Diclofenac (Sodium). This product is intended for research and analytical applications. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3]. IC50 & Target:IC50: 4 nM (Human COX-1, in CHO cells), 1.3 nM (Human COX-2, in CHO cells)[1], 5.1 μM (Ovine COX-1), 0.84 μM (Ovine COX-2)[2]
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