Serotonin (hydrochloride)
CAS No. : 153-98-0
(Synonyms: 5-Hydroxytryptamine (hydrochloride); 5-HT (hydrochloride))
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|---|---|---|
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| 100mg | $80 | In-stock |
| 250mg | $160 | In-stock |
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| Cat. No. : | HY-B1473 |
| M.Wt: | 212.68 |
| Formula: | C10H13ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
IC50 & Target:5-HT receptor[1]
Ki: 44 μM (COMT)[1]
In Vitro:Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT[1].
In Vivo:Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)[1].
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