Oxypertine
CAS No. : 153-87-7
(Synonyms: WIN-18501-2)
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $475 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1515 | In-stock |
| 100mg | $2425 | In-stock |
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| Cat. No. : | HY-119677 |
| M.Wt: | 379.50 |
| Formula: | C23H29N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Oxypertine (WIN-18501-2) is a neuroprotective agent. Oxypertine shows high affinity for the 5-HT2 and dopamine D2 receptors with Kis of 8.6 nM and 30 nM, respectively. Oxypertine can be used in the research of neurological conditions, such as anxiety and schizophrenia[1][2][3][4].
In Vitro:Oxypertine (0.44 nM-26 μM, 15 min) antagonizes dopamine and 5-HT induced contractions of the rat isolated vas deferens[1].
Oxypertine (8.8 nM, 15 min) reduces the contractions evoked by transmural stimulation of the vas deferens[1].
In Vivo:Oxypertine (10 and 35 mg/kg, i.p.) causes an obvious dose-related depletion in the levels of norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) in various discrete regions of the rat brain[2].
Oxypertine (0.625-20 mg/kg, i.p.) inhibits stereotyped behaviour induced by both amphetamine and apomorphine in rats[3].
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