AB-MECA
CAS No. : 152918-26-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $72 | In-stock |
| 5mg | $288 | In-stock |
| 10mg | $460 | In-stock |
| 25mg | $920 | In-stock |
| 50mg | $1472 | In-stock |
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| Cat. No. : | HY-19365 |
| M.Wt: | 399.40 |
| Formula: | C18H21N7O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 55 mg/mL (ultrasonic) |
AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level[1][2][3][4].
In Vitro:AB-MECA (1, 10, 100 μM; 24 hours) shows dose-dependent cytotoxicity in human lung cancer cell line A549[2].
[125I]AB-MECA has KD values for binding to A3 receptors in transfected CHO cells and in RBL-2H3 cells are 1.48 and 3.61 nM, respectively[3].
In Vivo:AB-MECA (3 ug/kg; iv) enhances plasma histamine level in mouse[4].
AB-MECA (0.3 mg/kg; iv) enhances antigen-induced bronchoconstriction in male albino guinea pigs, weighing 180-220 g[5].
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