Piclidenoson
CAS No. : 152918-18-8
(Synonyms: IB-MECA; CF-101)
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $112 | In-stock |
| 25mg | $236 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $590 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13591 |
| M.Wt: | 510.29 |
| Formula: | C18H19IN6O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 45 mg/mL |
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19[1][2][3][4].
IC50 & Target: A3AR[2]
In Vitro: Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82 μM and 1.2 μM in OVCAR-3 cells and Caov-4 cells, respectively[2].
Piclidenoson (0.0001-100 μM; 48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines, with IC50s of 32.14 μM and 45.37 μM for OVCAR-3 and Caov-4 cells, respectively[2].
Piclidenoson (0.001-100 μM; 48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway[2].
Piclidenoson induces apoptosis via the mitochondrial signaling pathway[2].
In Vivo: Piclidenoson (105 μg/kg; i.p.) enhances survival of γ-irradiated mice[3].
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