NE 10790
CAS No. : 152831-36-2
(Synonyms: 3-PEHPC)
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $527 | In-stock |
| 100mg | $895 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16011 |
| M.Wt: | 247.14 |
| Formula: | C8H10NO6P |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic;adjust pH to 6 with NaOH);0.1 M NaOH : 20 mg/mL (ultrasonic;adjust pH to 6 with NaOH) |
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. IC50 & Target: FPP synthase[1]. In Vitro: NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].
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