GNE-955
CAS No. : 1527523-39-2
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| Cat. No. : | HY-101783 |
| M.Wt: | 416.48 |
| Formula: | C22H24N8O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
IC50 & Target: Ki: 0.022 nM (Pim1), 0.11 nM (Pim2), 0.041 nM (Pim3)[1]
In Vitro: GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment[1].
GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.[1]
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