Sevelamer (hydrochloride)
CAS No. : 152751-57-0
| Size | Price | Stock |
|---|---|---|
| 100mg | $50 | In-stock |
| 500mg | $125 | In-stock |
| 1g | $160 | In-stock |
| 5g | $256 | In-stock |
| 10g | $332 | In-stock |
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| Cat. No. : | HY-13995A |
| M.Wt: | 1000.00 |
| Formula: | (C3H7N.C3H5ClO)x.xHCl |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL |
Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3].
In Vitro:Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL)[2].
In Vivo:Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice[3].
Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice[3].
Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression[3].
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