PFE-360
CAS No. : 1527475-61-1
(Synonyms: PF-06685360)
| Size | Price | Stock |
|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $1000 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120085 |
| M.Wt: | 308.34 |
| Formula: | C16H16N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 10.42 mg/mL (ultrasonic) |
PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2]. IC50 & Target: IC50: 2.3 nM (LRRK2 in vivo) [1][2]. In Vivo: PFE-360 (4 mg/kg and 7.5 mg/kg, orally, BID, 10-12 weeks) treatment potently decreases the LRRK2-pSer935/total LRRK2 ratio, with no significant adverse effects[1].
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